How good are quantitative complementation tests?
نویسنده
چکیده
Several recent studies have used quantitative complementation tests to identify relatively short chromosome regions that contain genes that influence life span and to screen for candidate life-span genes in flies. The methodology and logic of quantitative complementation tests are described. Arguments are presented that suggest that these tests may be misleading because there is a substantial, but unknown, likelihood of false positive results. The arguments are supported by the published results of quantitative complementation tests.
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عنوان ژورنال:
- Science of aging knowledge environment : SAGE KE
دوره 2004 12 شماره
صفحات -
تاریخ انتشار 2004